Pharmacokinetic/Pharmacodynamic Analysis of High-Dose Daptomycin in Combination with Continuous Infusion Ceftobiprole in a Case Series of Documented Staphylococcal Bacteremia or Endocarditis: Is There Any Room for TDM-Guided Dosing Reduction?

Background: Staphylococcal bloodstream infections (BSIs) and infective endocarditis (IE) are associated with high morbidity and mortality. Among the different antimicrobial combination strategies proposed to enhance antibacterial activity, the association of daptomycin and ceftobiprole may be valuab...

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Egile Nagusiak:	Pier Giorgio Cojutti, Renato Pascale, Andrea Grechi, Simone Ambretti, Pierluigi Viale, Federico Pea
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	MDPI AG 2026-03-01
Saila:	Antibiotics
Gaiak:	daptomycin continuous infusion ceftobiprole bacteremia endocarditis PK/PD target attainment model-informed precision dosing (MIPD)
Sarrera elektronikoa:	https://www.mdpi.com/2079-6382/15/3/315
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