A pyridinesulfonamide derivative FD268 suppresses cell proliferation and induces apoptosis via inhibiting PI3K pathway in acute myeloid leukemia.

Aberration of PI3K signaling pathway has been confirmed to be associated with several hematological malignancies including acute myeloid leukemia (AML). FD268, a pyridinesulfonamide derivative characterized by the conjugation of 7-azaindole group, is a newly identified PI3K inhibitor showing high po...

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Principais autores:	Yi Chen, Tianze Wu, Chengbin Yang, Mingzhu Lu, Zhenxia Chen, Mingli Deng, Yu Jia, Yongtai Yang, Xiaofeng Liu, Hongyan Wang, Yun Ling, Lei Lu, Yaming Zhou
Formato:	Artigo
Idioma:	Inglês
Publicado:	Public Library of Science (PLoS) 2022-01-01
Series:	PLoS ONE
Acceso en liña:	https://doi.org/10.1371/journal.pone.0277893
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