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Highly efficient generation of glutamatergic/cholinergic NT2-derived postmitotic human neurons by short-term treatment with the nucleoside analogue cytosine β-d-arabinofuranoside

The human NTERA2/D1 (NT2) cells generate postmitotic neurons (NT2N cells) upon retinoic acid (RA) treatment and are functionally integrated in the host tissue following grafting into the rodent and human brain, thus representing a promising source for neuronal replacement therapy. Yet the major limi...

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Autors principals: Imanol González-Burguera, Ana Ricobaraza, Xabier Aretxabala, Sergio Barrondo, Gontzal García del Caño, Maider López de Jesús, Joan Sallés
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2016-03-01
Col·lecció:Stem Cell Research
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Accés en línia:http://www.sciencedirect.com/science/article/pii/S1873506116000805
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