Potential prophylactic effect of chemical chaperones for alleviation of endoplasmic reticulum stress in experimental diabetic cataract

Abstract Background Imbalance between protein synthesis and endoplasmic reticulum (ER) capacity to modify and fold proteins lead to the accumulation of unfolded proteins resulting in ER stress and apoptosis. Chaperones are major defense molecules assisting in protein folding, transport, and cellular...

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Principais autores:	Amany Abdel-Ghaffar, Ghada G. Elhossary, Atef M. Mahmoud, Amany H. M. Elshazly, Olfat A. Hassanin, Anisa Saleh, Sahar M. Mansour, Fatma G. Metwally, Laila K. Hanafy, Sawsan H. Karam, Hager E. Amer, Nadia A. Samy, Ahmed Mostafa Ata
Formato:	Artigo
Idioma:	Inglês
Publicado em:	SpringerOpen 2019-04-01
coleção:	Bulletin of the National Research Centre
Assuntos:	ER stress Diabetes mellitus Cataract Chaperones TUDCA 4-PBA
Acesso em linha:	http://link.springer.com/article/10.1186/s42269-019-0089-7
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