Safety and potential effects of intrathecal injection of allogeneic human umbilical cord mesenchymal stem cell-derived exosomes in complete subacute spinal cord injury: a first-in-human, single-arm, open-label, phase I clinical trial

Abstract Objective Neurological and functional impairments are commonly observed in individuals with spinal cord injury (SCI) due to insufficient regeneration of damaged axons. Exosomes play a crucial role in the paracrine effects of mesenchymal stem cells (MSCs) and have emerged as a promising ther...

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Autori principali:	Mohammadhosein Akhlaghpasand, Roozbeh Tavanaei, Maede Hosseinpoor, Kaveh Oraii Yazdani, Afsane Soleimani, Mojtaba Yousefi Zoshk, Masoud Soleimani, Mohsen Chamanara, Mahdi Ghorbani, Mohammad Deylami, Alireza Zali, Reza Heidari, Saeed Oraee-Yazdani
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2024-08-01
Serie:	Stem Cell Research & Therapy
Soggetti:	Spinal cord injury Exosomes Mesenchymal stem cells Neuroprotection
Accesso online:	https://doi.org/10.1186/s13287-024-03868-0
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