Coarse-grained molecular simulation of epidermal growth factor receptor protein tyrosine kinase multi-site self-phosphorylation.
Upon the ligand-dependent dimerization of the epidermal growth factor receptor (EGFR), the intrinsic protein tyrosine kinase (PTK) activity of one receptor monomer is activated, and the dimeric receptor undergoes self-phosphorylation at any of eight candidate phosphorylation sites (P-sites) in eithe...
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| Format: | Artigo |
| Sprache: | Inglês |
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Public Library of Science (PLoS)
2014-01-01
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| Schriftenreihe: | PLoS Computational Biology |
| Online-Zugang: | http://europepmc.org/articles/PMC3894164?pdf=render |
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