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Genetic Deficiency of Hyaluronan Synthase 2 in the Developing Limb Mesenchyme Impairs Postnatal Synovial Joint Formation

Hyaluronan, a key component of the extracellular matrix, plays a crucial role in joint development and maintenance. In order to determine the role of hyaluronan function in joint development and homeostasis, conditional loss-of-function experiments of Hyaluronan Synthase 2 (<i>Has2</i>) were carried...

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Principais autores: Yingcui Li, Alexander Tress, Peter Maye, Kemar Edwards, Asiona Findletar, Nathaniel A. Dyment, Yu Yamaguchi, David W. Rowe, Gengyun Le-Chan, Sunny S. K. Chan, Kevin W.-H. Lo
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2025-05-01
Serier:Biomedicines
Fag:
synovial joint formation
limb development
cartilage homeostasis
hyaluronan
hyaluronan synthase 2 (<i>Has2</i>)
Online adgang:https://www.mdpi.com/2227-9059/13/6/1324
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