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Effects of Silymarin on the In Vivo Pharmacokinetics of Simvastatin and Its Active Metabolite in Rats

Herein, the effect of silymarin pretreatment on the pharmacokinetics of simvastatin in rats was evaluated. To ensure the accuracy of the results, a rapid and sensitive UPLC−MS/MS method was established for simultaneous quantification of simvastatin (SV) and its active metabolite simvastatin ac...

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Bibliográfalaš dieđut
Váldodahkkit: Ying Li, Yin Wu, Ya-Jing Li, Lu Meng, Cong-Yang Ding, Zhan-Jun Dong
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: MDPI AG 2019-04-01
Ráidu:Molecules
Fáttát:
Liŋkkat:https://www.mdpi.com/1420-3049/24/9/1666
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