In vivo validation of novel non-invasive PHP.eB AAVs as a potential therapeutic approach for alpha-synucleinopathies

Abstract Parkinson’s disease (PD) is characterized by the accumulation of alpha-synuclein (aSyn) aggregates in specific brain regions, which are likely to be the disease-causing entities. Herein, we employed novel, systemically administered, brain-penetrating viral vectors (PHP.eB AAVs) in order to...

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Prif Awduron:	Maria Fouka, Iraklis Tsakogias, Elena-Georgia Gialinaki, Athanasios Stavropoulos, Christiane Volbracht, Louis De Muynck, Diederik Moechars, Ronald Melki, George K. Tofaris, Leonidas Stefanis, Maria Xilouri
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	BMC 2025-09-01
Cyfres:	Acta Neuropathologica Communications
Pynciau:	AAV-PHP.eB Alpha-Synuclein Dopaminergic system microRNAs Pre-formed fibrils shRNAs
Mynediad Ar-lein:	https://doi.org/10.1186/s40478-025-02121-w
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