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Engineering Enhanced Immunogenicity of Surface-Displayed Immunogens in a Killed Whole-Cell Genome-Reduced Bacterial Vaccine Platform Using Class I Viral Fusion Peptides

<b>Background/Objectives</b>: New vaccine platforms that rapidly yield low-cost, easily manufactured vaccines are highly desired, yet current approaches lack key features. We developed the Killed Whole-Cell/Genome-Reduced Bacteria (KWC/GRB) platform, which uses a genome-reduced Gram-negative chassis...

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Principais autores: Juan Sebastian Quintero-Barbosa, Yufeng Song, Frances Mehl, Shubham Mathur, Lauren Livingston, Xiaoying Shen, David C. Montefiori, Joshua Tan, Steven L. Zeichner
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2025-12-01
coleção:Vaccines
Assuntos:
vaccine platform
killed whole-cell
genome-reduced bacteria
autotransporter
bacterin
Acesso em linha:https://www.mdpi.com/2076-393X/14/1/14
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