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What fraction of cellular DNA turnover becomes cfDNA?

Cell-free DNA (cfDNA) tests use small amounts of DNA in the bloodstream as biomarkers. While it is thought that cfDNA is largely released by dying cells, the proportion of dying cells' DNA that reaches the bloodstream is unknown. Here, we integrate estimates of cellular turnover rates to calculate t...

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Autori principali: Ron Sender, Elad Noor, Ron Milo, Yuval Dor
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications Ltd 2024-02-01
Serie:eLife
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Accesso online:https://elifesciences.org/articles/89321
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