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Deletion of the N-terminal 400 amino acids of DPV pUL36 attenuated virulence and conferred effective protection against virulent challenge

Duck plague virus (DPV) causes a highly contagious disease in ducks, resulting in substantial economic losses to the poultry industry. The large tegument protein pUL36 is conserved among herpesviruses and plays critical roles in viral replication and pathogenesis. However, the function of its unique...

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Principais autores: Qiao Yang, Hongxin Yu, Lin Ai, Mingshu Wang, Ying Wu, Bin Tian, Yitong Yang, Renyong Jia, Dekang Zhu, Shun Chen, Mafeng Liu, Xinxin Zhao, Shaqiu Zhang, Juan Huang, Xumin Ou, Di Sun, Yu He, Zhen Wu, Ling Zhang, Yanling Yu, Anchun Cheng
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2026-08-01
coleção:Poultry Science
Assuntos:
Duck plague virus
pUL36
Virulence attenuation
Protective immunity
Live-attenuated vaccine
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S0032579126007297
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