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Evidence of focusing the MHC class I immunopeptidome by tapasin

Major Histocompatibility Complex class I (MHC-I) molecules bind and present peptides to cytotoxic T cells, protecting against pathogens and cancer. MHC-I is highly polymorphic and each allotype is promiscuous, and capable of binding a unique and diverse repertoire of peptide ligands. The peptide edi...

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Autori principali: Rachel Darley, Patricia T. Illing, Patrick Duriez, Alistair Bailey, Anthony W. Purcell, Andy van Hateren, Tim Elliott
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2025-05-01
Serie:Frontiers in Immunology
Soggetti:
MHC class I
tapasin
TAPBPR
peptide editing
peptide selection
immunopeptidome
Accesso online:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1563789/full
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