Nalmefene enhances the remyelinating ability of nalfurafine when administered therapeutically at very low doses during experimental autoimmune encephalomyelitis

Abstract Objectives Multiple sclerosis is an immune‐mediated inflammatory disease of the central nervous system. Recently, kappa opioid receptor (KOR) agonists were found to promote remyelination and recovery in models of demyelination. However, the side effects of many full KOR agonists limit clini...

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Detalhes bibliográficos

Principais autores:	Lisa Denny, Katharina Robichon, Nikki Templeton, Mackenzie Kiernan, Thomas E Prisinzano, Bronwyn M Kivell, Anne Camille La Flamme
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2025-01-01
coleção:	Clinical & Translational Immunology
Assuntos:	experimental autoimmune encephalomyelitis kappa opioid receptor agonist mu opioid receptor antagonist nalfurafine nalmefene
Acesso em linha:	https://doi.org/10.1002/cti2.70069
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