Dronedarone hydrochloride (DH) induces pancreatic cancer cell death by triggering mtDNA-mediated pyroptosis

Abstract Pancreatic cancer is one of the leading causes of cancer-associated mortality, with a poor treatment approach. Previous study has shown that inducing pyroptosis in pancreatic ductal adenocarcinoma (PDAC) slows the growth of PDACs, implying that pyroptosis inducers are potentially effective...

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Hlavní autoři:	Ming-Qiao Li, Yu-Qi He, Meng-Ni Zhang, Wan Tang, Ya Tan, Yue Cheng, Mei Yang, Nan Zhao, Ling Li, Si-Rui Yu, Ruo-Lan Li, Qiong Pan, Ming-Yue Wu, Jin Chai
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Publishing Group 2024-10-01
Edice:	Cell Death and Disease
On-line přístup:	https://doi.org/10.1038/s41419-024-07102-w
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