IGF-1 promotes Brn-4 expression and neuronal differentiation of neural stem cells via the PI3K/Akt pathway.

Our previous studies indicated that transcription factor Brn-4 is upregulated in the surgically denervated hippocampus in vivo, promoting neuronal differentiation of hippocampal neural stem cells (NSCs) in vitro. The molecules mediating Brn-4 upregulation in the denervated hippocampus remain unknown...

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Detalhes bibliográficos

Principais autores:	Xinhua Zhang, Lei Zhang, Xiang Cheng, Yuxiu Guo, Xiaohui Sun, Geng Chen, Haoming Li, Pengcheng Li, Xiaohui Lu, Meiling Tian, Jianbing Qin, Hui Zhou, Guohua Jin
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2014-01-01
coleção:	PLoS ONE
Acesso em linha:	https://doi.org/10.1371/journal.pone.0113801
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