Pgk1 activation restores endothelial metabolic homeostasis to alleviate vascular aging and atherosclerosis

Abstract Terazosin (TZ), a well-known antagonist of the α1-adrenergic receptor (α1-AR), has demonstrated protective effects on vascular endothelial cells (ECs) and reduced vascular stiffness in clinical studies. Endothelial dysfunction and oxidative stress are central drivers of cardiometabolic dise...

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Principais autores:	Jinhong Lu, Jianji Wang, Yu Liu, Cuntai Zhang, Guojun Zhang, Yipeng Ge, Lei Liu
格式:	Artigo
語言:	Inglês
出版:	BMC 2025-11-01
叢編:	Cardiovascular Diabetology
主題:	Terazosin Endothelial senescence Atherosclerosis Pgk1 Vascular leakage VEGFA
在線閱讀:	https://doi.org/10.1186/s12933-025-02976-2
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