Generating an organ-deficient animal model using a multi-targeted CRISPR-Cas9 system
Abstract Gene-knockout animal models with organ-deficient phenotypes used for blastocyst complementation are generally not viable. Animals need to be maintained as heterozygous mutants, and homozygous mutant embryos yield only one-fourth of all embryos. In this study, we generated organ-deficient em...
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| Principais autores: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Portfolio
2024-05-01
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| Series: | Scientific Reports |
| Acceso en liña: | https://doi.org/10.1038/s41598-024-61167-3 |
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