Mirogabalin activates the descending noradrenergic system by binding to the α2δ-1 subunit of voltage-gated Ca2+ channels to generate analgesic effects

Gabapentinoids such as gabapentin and pregabalin, which bind specifically to the α2δ subunit of voltage-gated Ca2+ channels, are used for first-line treatment of neuropathic pain. Here, we examined the analgesic effect of mirogabalin besilate (referred to simply as mirogabalin), a novel gabapentinoi...

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Hlavní autoři:	Misa Oyama, Shun Watanabe, Takashi Iwai, Mitsuo Tanabe
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2021-05-01
Edice:	Journal of Pharmacological Sciences
Témata:	Mirogabalin Gabapentinoid Neuropathic pain α2δ-1 subunit Descending noradrenergic pain inhibitory system
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S1347861321000037
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