Thermoregulatory adaptations to cold in C3H/HeJ mice are independent of ADRB3 signaling

Abstract Housing conditions and mouse strain significantly influence metabolic phenotypes, affecting the translational relevance of preclinical studies. Although C57BL/6J (C57) mice are widely used, their thermogenic and adrenergic profiles may not fully reflect human physiology. This study compared...

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Autores principales:	Sarra Beji, Mathilde Mouchiroud, Yves Gélinas, Mathieu Laplante, Andréanne Michaud, Alexandre Caron
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Portfolio 2026-02-01
Colección:	Scientific Reports
Materias:	Brown adipose tissue Energy metabolism Thermoregulation Cold Mouse strains Adrenergic receptor
Acceso en línea:	https://doi.org/10.1038/s41598-026-38538-z
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