Indole-carbohydrazide linked phenoxy-1,2,3-triazole-N-phenylacetamide derivatives as potent α-glucosidase inhibitors: design, synthesis, in vitro α-glucosidase inhibition, and computational studies

Abstract Background A new series of indole-carbohydrazide-phenoxy-1,2,3-triazole-N-phenylacetamide hybrids 11a–o was designed based on molecular hybridization of the active pharmacophores of the potent α-glucosidase inhibitors. These compounds were synthesized and evaluated against α-glucosidase. Me...

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Autori principali:	Mehdi Emadi, Fahimeh Mosavizadeh-Marvest, Ali Asadipour, Yaghoub Pourshojaei, Samanesadat Hosseini, Somayeh Mojtabavi, Mohammad Ali Faramarzi, Bagher Larijani, Maryam Mohammadi-Khanaposhtani, Mohammad Mahdavi
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2023-06-01
Serie:	BMC Chemistry
Soggetti:	Indole Carbohydrazide 1,2,3-Triazole α-Glucosidase N-phenylacetamide
Accesso online:	https://doi.org/10.1186/s13065-023-00971-w
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