Loss-of-function mutations in the histone methyltransferase EZH2 promote chemotherapy resistance in AML

Abstract Chemotherapy resistance is the main impediment in the treatment of acute myeloid leukaemia (AML). Despite rapid advances, the various mechanisms inducing resistance development remain to be defined in detail. Here we report that loss-of-function mutations (LOF) in the histone methyltransfer...

وصف كامل

التفاصيل البيبلوغرافية

المؤلفون الرئيسيون:	Julia M. Kempf, Sabrina Weser, Michael D. Bartoschek, Klaus H. Metzeler, Binje Vick, Tobias Herold, Kerstin Völse, Raphael Mattes, Manuela Scholz, Lucas E. Wange, Moreno Festini, Enes Ugur, Maike Roas, Oliver Weigert, Sebastian Bultmann, Heinrich Leonhardt, Gunnar Schotta, Wolfgang Hiddemann, Irmela Jeremias, Karsten Spiekermann
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	Nature Portfolio 2021-03-01
سلاسل:	Scientific Reports
الوصول للمادة أونلاين:	https://doi.org/10.1038/s41598-021-84708-6
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!