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Intracerebral Injection of Extracellular Vesicles from Mesenchymal Stem Cells Exerts Reduced Aβ Plaque Burden in Early Stages of a Preclinical Model of Alzheimer’s Disease

Bone marrow Mesenchymal Stem Cells (BM-MSCs), due to their strong protective and anti-inflammatory abilities, have been widely investigated in the context of several diseases for their possible therapeutic role, based on the release of a highly proactive secretome composed of soluble factors and Ext...

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Principais autores: Chiara A. Elia, Matteo Tamborini, Marco Rasile, Genni Desiato, Sara Marchetti, Paolo Swuec, Sonia Mazzitelli, Francesca Clemente, Achille Anselmo, Michela Matteoli, Maria Luisa Malosio, Silvia Coco
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2019-09-01
coleção:Cells
Assuntos:
bone marrow mesenchymal stem cells
extracellular vesicles
Alzheimer’s disease
APPswe/PS1dE9 AD mice
Neprilysin
dystrophic neuritis
SMI
Aβ plaques
Acesso em linha:https://www.mdpi.com/2073-4409/8/9/1059
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