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Incorporating Phylogenetic Information in Microbiome Differential Abundance Studies Has No Effect on Detection Power and FDR Control

We consider the problem of incorporating evolutionary information (e.g., taxonomic or phylogenic trees) in the context of metagenomics differential analysis. Recent results published in the literature propose different ways to leverage the tree structure to increase the detection rate of differentia...

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Principais autores: Antoine Bichat, Jonathan Plassais, Christophe Ambroise, Mahendra Mariadassou
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020-04-01
Serier:Frontiers in Microbiology
Fag:
microbiome
metagenomics
multiple testing
false discovery rate
correlation
phylogeny
Online adgang:https://www.frontiersin.org/article/10.3389/fmicb.2020.00649/full
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