DNA methylation and hydroxymethylation combined with transcriptional profiling identify key regulators of hyperoxia-induced bronchopulmonary dysplasia

Abstract Background Hyperoxia-induced bronchopulmonary dysplasia (BPD) is a major cause of lung injury in premature infants. Epigenetics, particularly DNA (hydroxy)methylation, has been identified as a crucial regulator of BPD pathogenesis. This study aimed to reveal key regulators and pathogenic ge...

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Huvudupphov:	Hui-Tao Li, Tao Qian, Hao-Min Zhang, Qiu-Hua Li, Yi-Yun Ma, Yi-Fan Li, Zi-Lu Huang, Dong-Shan Han, Yuan-Ye Dang, Ying-Ying Xiao, Ling Sun, Xue-Yu Chen, Xue-Yan Jiang
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	BMC 2025-07-01
Serie:	Clinical Epigenetics
Ämnen:	Bronchopulmonary dysplasia Hyperoxia-induced lung injury DNA methylation DNA hydroxymethylation Epigenetics
Länkar:	https://doi.org/10.1186/s13148-025-01926-9
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