Holes in the Glycan Shield of the Native HIV Envelope Are a Target of Trimer-Elicited Neutralizing Antibodies

A major advance in the search for an HIV vaccine has been the development of a near-native Envelope trimer (BG505 SOSIP.664) that can induce robust autologous Tier 2 neutralization. Here, potently neutralizing monoclonal antibodies (nAbs) from rabbits immunized with BG505 SOSIP.664 are shown to reco...

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Detalhes bibliográficos

Principais autores:	Laura E. McCoy, Marit J. van Gils, Gabriel Ozorowski, Terrence Messmer, Bryan Briney, James E. Voss, Daniel W. Kulp, Matthew S. Macauley, Devin Sok, Matthias Pauthner, Sergey Menis, Christopher A. Cottrell, Jonathan L. Torres, Jessica Hsueh, William R. Schief, Ian A. Wilson, Andrew B. Ward, Rogier W. Sanders, Dennis R. Burton
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2016-08-01
coleção:	Cell Reports
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2211124716310208
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