An Unexpected Result of Base-Promoted Rearrangement of 4a-Acetyl-8a-hydroxydecahydroquinazoline-2-thione

Treatment of 4a-acetyl-8a-hydroxydecahydroquinazoline-2-thione with NaH in acetonitrile leads to its isomerization into 1-hydroxy-1-methyl-3-thioxo-2,4-diazaspiro[5.5]undecan-7-one followed by the C1-C6 bond cleavage to give <i>N</i>-acetyl-<i>N</i>’-[(2-oxocyclohexyl)methyl]thiourea. The starting c...

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Autori principali:	Anatoly D. Shutalev, Anastasia A. Fesenko
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2022-11-01
Serie:	Chemistry Proceedings
Soggetti:	<i>N</i>-(azidomethyl)thiourea <i>N</i>-(tosylmethyl)thiourea 2-acetylcyclohexanone 4a-acetyl-8a-hydroxydecahydroquinazoline-2-thione rearrangement
Accesso online:	https://www.mdpi.com/2673-4583/12/1/3
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