Alteration of cellular behavior and response to PI3K pathway inhibition by culture in 3D collagen gels.
Most investigations into cancer cell drug response are performed with cells cultured on flat (2D) tissue culture plastic. Emerging research has shown that the presence of a three-dimensional (3D) extracellular matrix (ECM) is critical for normal cell behavior including migration, adhesion, signaling...
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| Principais autores: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Public Library of Science (PLoS)
2012-01-01
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| Serija: | PLoS ONE |
| Online dostop: | https://doi.org/10.1371/journal.pone.0048024 |
| Oznake: |
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