Covalent inhibitor targets KRasG12C: A new paradigm for drugging the undruggable and challenges ahead
KRAS is one of the most commonly mutated oncogenes in cancers and therapeutics directly targeting the KRas have been challenging. Among the different known mutants, KRasG12C has been proved to be successfully targeted recently. Several covalent inhibitors selectively targeting KRasG12C have shown pr...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
KeAi Communications Co., Ltd.
2023-03-01
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| Серии: | Genes and Diseases |
| Предметы: | |
| Online-ссылка: | http://www.sciencedirect.com/science/article/pii/S2352304221001094 |
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