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Total flavonoids of Rhizoma drynariae targets NRF2-mediated anti-ferroptosis in osteoblasts to promote induced membrane osteogenesis

Abstract Background Induced membrane technique (IMT), a novel approach for reconstructing critical-size bone defect, encounters the challenge of lengthy mineralization time after bone grafting. Total flavonoids of Rhizoma drynariae (TFRD), the extracts from dried rhizome of Drynaria roosii Nakaike,...

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Principais autores: Shuyuan Li, Dawen Yang, Zhanpeng Zeng, Qunbin Cai, Qishi Zhou
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-03-01
Serier:Chinese Medicine
Fag:
Total flavonoids of Rhizoma drynariae
Induced membrane technique
NRF2
Ferroptosis
Bone defect
Online adgang:https://doi.org/10.1186/s13020-026-01347-7
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