Epidermal Growth Factor Receptor (EGFR) gene copy number (GCN) correlates with clinical activity of irinotecan-cetuximab in K-RAS wild-type colorectal cancer: a fluorescence in situ (FISH) and chromogenic in situ hybridization (CISH) analysis

<p>Abstract</p> <p>Background</p> <p>K-RAS wild type colorectal tumors show an improved response rate to anti-EGFR monoclonal antibodies. Nevertheless 70% to 40% of these patients still does not seem to benefit from this therapeutic approach. FISH EGFR GCN has been previously demonstrated to correla...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Scartozzi Mario, Bearzi Italo, Mandolesi Alessandra, Pierantoni Chiara, Loupakis Fotios, Zaniboni Alberto, Negri Francesca, Quadri Antonello, Zorzi Fausto, Galizia Eva, Berardi Rossana, Biscotti Tommasina, Labianca Roberto, Masi Gianluca, Falcone Alfredo, Cascinu Stefano
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	BMC 2009-08-01
Цуврал:	BMC Cancer
Онлайн хандалт:	http://www.biomedcentral.com/1471-2407/9/303
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!