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Minor Isozymes Tailor Yeast Metabolism to Carbon Availability

ABSTRACT Isozymes are enzymes that differ in sequence but catalyze the same chemical reactions. Despite their apparent redundancy, isozymes are often retained over evolutionary time, suggesting that they contribute to fitness. We developed an unsupervised computational method for identifying environ...

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Principais autores: Patrick H. Bradley, Patrick A. Gibney, David Botstein, Olga G. Troyanskaya, Joshua D. Rabinowitz
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2019-02-01
Serier:mSystems
Fag:
cerevisiae
duplicates
genomics
isozymes
metabolomics
paralogs
Online adgang:https://journals.asm.org/doi/10.1128/msystems.00170-18
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