Mechanisms of corticosteroid insensitivity in COPD alveolar macrophages exposed to NTHi

Abstract Background Non-typeable Haemophilus influenza (NTHi) infection is common in COPD. Corticosteroids can have limited therapeutic effects in COPD patients. NTHi causes corticosteroid insensitive cytokine production from COPD alveolar macrophages. We investigated the mechanisms by which NTHi ca...

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Autors principals:	Rana M. Khalaf, Simon R. Lea, Hannah J. Metcalfe, Dave Singh
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2017-04-01
Col·lecció:	Respiratory Research
Matèries:	Chronic Obstructive Pulmonary Disease Glucocorticoid Receptor Chronic Obstructive Pulmonary Disease Patient Alveolar Macrophage Macrophage Polarisation
Accés en línia:	http://link.springer.com/article/10.1186/s12931-017-0539-4
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