METTL16/IGF2BP2 axis enhances malignant progression and DDP resistance through up-regulating COL4A1 by mediating the m6A methylation modification of LAMA4 in hepatocellular carcinoma

Abstract Background Hepatocellular carcinoma (HCC) is the third most common malignant tumor after gastric cancer and esophageal cancer, which is a serious threat to human health. Methyltransferase-like protein 16 (METTL16) regulates the occurrence and development of various cancers, but its molecula...

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Hauptverfasser:	Liming Cao, Wei Bi
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2025-04-01
Schriftenreihe:	Cell Division
Schlagworte:	Hepatocellular carcinoma Methyltransferase-like protein 16 Laminin subunit alpha 4 Collagen type IV alpha 1 chain Insulin like growth factor 2 mRNA binding protein 2
Online-Zugang:	https://doi.org/10.1186/s13008-025-00152-2
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