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[99mTc]Tc-Sestamibi Bioaccumulation Can Induce Apoptosis in Breast Cancer Cells: Molecular and Clinical Perspectives

The aim of this study was to investigate the possible role of [99mTc]Tc-Sestamibi in the regulation of cancer cell proliferation and apoptosis. To this end, the in vivo values of [99mTc]Tc-Sestamibi uptake have been associated with the in-situ expression of both Ki67 and caspase-3. For in vitro inve...

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Main Authors: Nicoletta Urbano, Manuel Scimeca, Rita Bonfiglio, Alessandro Mauriello, Elena Bonanno, Orazio Schillaci
Format: Artigo
Language:Inglês
Published: MDPI AG 2021-03-01
Series:Applied Sciences
Subjects:
99mTc-sestamibi
breast-specific γ imaging
breast cancer
apoptosis
theragnostic
Online Access:https://www.mdpi.com/2076-3417/11/6/2733
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