PROBING OF Cu2+ IONS BINDING TO Aβ(5−16) PEPTIDE USING ITC MEASUREMENTS AND MD SIMULATIONS

It is shown that probably three residues: His6, His14 and His16 in the original sequence Aβ(1−42) serve as metal-binding sites for Cu2+ ions. On the other hand, there is a possibility that only one of them plays a crucial role in the formation of the {Aβ(1−42) --Cu2+} complex. The isothermal titrat...

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Autori principali:	JOANNA MAKOWSKA, WIOLETTA ŻMUDZIŃSKA, DARIUSZ WYRZYKOWSKI, KRZYSZTOF BRZOZOWSKI, HONORATA ZBLEWSKA, LECH CHMURZYŃSKI
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Gdańsk University of Technology 2016-10-01
Serie:	TASK Quarterly
Soggetti:	Aβ(5−16) fragments metal-peptide binding isothermal titration calorimetry molecular dynamics simulations
Accesso online:	https://journal.mostwiedzy.pl/TASKQuarterly/article/view/1831
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