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The increased matrix stiffness caused by LOXL2 activates Piezo1 channels to promote the migration and invasion of cervical cancer cells

Abstract Background Lymph node metastasis in cervical cancer (CC) is a significant contributor to mortality associated with this disease. Notably, CC with lymph node metastasis exhibits greater stiffness upon palpation compared to CC without such metastasis. Lysyl oxidase-like 2 (LOXL2), a member of...

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Principais autores: Tingting Liu, Hua Liang, Yang Li, Wenxin Liao, Juexiao Deng, Lanyue Zhang, Fujin Shen
Formato: Artigo
Idioma:Inglês
Publicado em: Springer 2025-04-01
coleção:Discover Oncology
Assuntos:
Piezo1
Matrix stiffness
Cervical cancer
Migration
Invasion
Acesso em linha:https://doi.org/10.1007/s12672-025-02456-9
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