U2 snRNA structure is influenced by SF3A and SF3B proteins but not by SF3B inhibitors.
U2 snRNP is an essential component of the spliceosome. It is responsible for branch point recognition in the spliceosome A-complex via base-pairing of U2 snRNA with an intron to form the branch helix. Small molecule inhibitors target the SF3B component of the U2 snRNP and interfere with A-complex fo...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Public Library of Science (PLoS)
2021-01-01
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| シリーズ: | PLoS ONE |
| オンライン･アクセス: | https://doi.org/10.1371/journal.pone.0258551 |
| タグ: |
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