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Targeting STAT6-mediated synovial macrophage activation improves pain in experimental knee osteoarthritis

Abstract Background Pain from osteoarthritis (OA) is one of the top causes of disability worldwide, but effective treatment is lacking. Nociceptive factors are released by activated synovial macrophages in OA, but depletion of synovial macrophages paradoxically worsens inflammation and tissue damage...

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Furkejuvvon:
Váldodahkkit: Garth Blackler, Yue Lai-Zhao, Joseph Klapak, Holly T. Philpott, Kyle K. Pitchers, Andrew R. Maher, Benoit Fiset, Logan A. Walsh, Elizabeth R. Gillies, C. Thomas Appleton
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: BMC 2024-03-01
Ráidu:Arthritis Research & Therapy
Fáttát:
Signal transducer and activator of transcription 6
macrophages
pain
osteoarthritis
Liŋkkat:https://doi.org/10.1186/s13075-024-03309-6
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