Ginsenoside Re binds Drp1 Leu94 across species to restore mitochondrial homeostasis via Atg1/ULK1-dependent fission-mitophagy coupling in age-related degeneration

Aging profoundly impacts the brain, serving as a primary driver of neurodegenerative diseases through mechanisms closely linked to mitochondrial dysfunction. Despite its clinical significance, the molecular mechanisms remain unclear, and safe, effective therapies are urgently needed. Here, leveragin...

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Detalhes bibliográficos

Principais autores:	Chenrong Jin, Juhui Qiao, Huilin Gong, Xiaorui Yu, Xinran Wang, Jiao Xi, Runying Mi, Shiting Yu, Daian Pan, Siming Wang, Xiaolin Tong, Daqing Zhao, Meichen Liu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2025-12-01
Colecção:	Pharmacological Research
Assuntos:	Ginsenoside Re Brain aging Mitochondrial dynamics Mitophagy axis Drp1 mutants
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S1043661825004682
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