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Nanocarriers for DNA Vaccines: Co-Delivery of TLR-9 and NLR-2 Ligands Leads to Synergistic Enhancement of Proinflammatory Cytokine Release

Adjuvants enhance immunogenicity of vaccines through either targeted antigen delivery or stimulation of immune receptors. Three cationic nanoparticle formulations were evaluated for their potential as carriers for a DNA vaccine, and muramyl dipeptide (MDP) as immunostimulatory agent, to induce and i...

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Kaydedildi:
Asıl Yazarlar: Johanna Poecheim, Simon Heuking, Livia Brunner, Christophe Barnier-Quer, Nicolas Collin, Gerrit Borchard
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: MDPI AG 2015-12-01
Seri Bilgileri:Nanomaterials
Konular:
adjuvants
toll-like receptor
NOD-like receptor
cationic nanoparticles
DNA vaccine
muramyl dipeptide
Online Erişim:http://www.mdpi.com/2079-4991/5/4/2317
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