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Unilateral Carotid Body Resection in Resistant Hypertension

Animal and human data indicate pathological afferent signaling emanating from the carotid body that drives sympathetically mediated elevations in blood pressure in conditions of hypertension. This first-in-man, proof-of-principle study tested the safety and feasibility of unilateral carotid body res...

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Hlavní autoři: Krzysztof Narkiewicz, MD, Laura E.K. Ratcliffe, BSc, MBBS, Emma C. Hart, PhD, Linford J.B. Briant, PhD, Marzena Chrostowska, PhD, Jacek Wolf, MD, Anna Szyndler, MD, Dagmara Hering, MD, Ana P. Abdala, PhD, Nathan Manghat, MD, Amy E. Burchell, MA, BMBCh, Claire Durant, PhD, Melvin D. Lobo, Paul A. Sobotka, MD, Nikunj K. Patel, MBBS, MD, James C. Leiter, MD, Zoar J. Engelman, PhD, Angus K. Nightingale, MB, BChir, MD, Julian F.R. Paton, PhD
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2016-08-01
Edice:JACC: Basic to Translational Science
Témata:
afferent drive
baroreceptor reflex
hypertension
hypoxia
peripheral chemoreceptor
sympathetic nervous system
On-line přístup:http://www.sciencedirect.com/science/article/pii/S2452302X1630064X
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