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Wybutosine hypomodification of tRNAphe activates HERVK and impairs neuronal differentiation

Summary: We previously reported that loss of function of TYW1 led to cerebral palsy with severe intellectual disability through reduced neural proliferation. However, whether TYW1 loss affects neural differentiation is unknown. In this study, we first demonstrated that TYW1 loss blocked the formatio...

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Principais autores: Chuanbo Sun, Ruirui Guo, Xiangyan Ye, Shiyi Tang, Manqi Chen, Pei Zhou, Miaomiao Yang, Caihua Liao, Hong Li, Bing Lin, Congwen Zang, Yifei Qi, Dingding Han, Yi Sun, Na Li, Dengna Zhu, Kaishou Xu, Hao Hu
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2024-05-01
Serier:iScience
Fag:
Developmental biology
Molecular biology
Neuroscience
Online adgang:http://www.sciencedirect.com/science/article/pii/S2589004224009702
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