Heterozygote advantage can explain the extraordinary diversity of immune genes

The majority of highly polymorphic genes are related to immune functions and with over 100 alleles within a population, genes of the major histocompatibility complex (MHC) are the most polymorphic loci in vertebrates. How such extraordinary polymorphism arose and is maintained is controversial. One...

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Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Mattias Siljestam, Claus Rueffler
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	eLife Sciences Publications Ltd 2024-11-01
Σειρά:	eLife
Θέματα:	allelic polymorpahism divergent allele advantage evolutionary invasion analysis negative frequency-dependent selection host-pathogen interaction
Διαθέσιμο Online:	https://elifesciences.org/articles/94587
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