Saliva-based lacosamide monitoring paves the way toward personalized epilepsy pharmacotherapy

Abstract Saliva, known for better patient compliance and simpler collection, is ideal for monitoring antiseizure medication (ASM) levels. This study aimed to validate saliva for measuring lacosamide, develop a pharmacokinetic (PK) model, and determine the optimal saliva concentration for seizure con...

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Detalhes bibliográficos

Principais autores:	Yoonhyuk Jang, Seon-Jae Ahn, Soyoung Lee, Yongmoo Kim, Han Sang Lee, Yoon-Kyung Lee, Yong Woo Shin, Soon-Tae Lee, Keun-Hwa Jung, Kyung-Il Park, Ki-Young Jung, Joo-Youn Cho, SeungHwan Lee, Kyung-Sang Yu, Kon Chu, In-Jin Jang, Sang Kun Lee
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-05-01
coleção:	Scientific Reports
Assuntos:	Saliva-based TDM Lacosamide Personalized medicine Lacosamide pharmacokinetics
Acesso em linha:	https://doi.org/10.1038/s41598-025-04044-x
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