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A pivotal role of GSK-3 in synaptic plasticity

Glycogen synthase kinase-3 (GSK-3) has many cellular functions. Recent evidence suggests that it plays a key role in certain types of synaptic plasticity, in particular a form of long-term depression (LTD) that is induced by the synaptic activation of N-methyl-D-aspartate (NMDA) receptors. In the...

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Principais autores: Clarrisa A Bradley, Stephane ePeineau, Changiz eTaghibiglou, Celine S Nicolas, Daniel J Whitcomb, Zuner A Bortolotto, Bong-Kiun eKaang, Kwangwook eCho, Yu-Tian eWang, Graham L Collingridge
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2012-02-01
coleção:Frontiers in Molecular Neuroscience
Assuntos:
Caspase 3
synaptic plasticity
Akt (PKB
AMPAR (AMPA receptor)
GSK-3 (Glycogen synthase kinase 3)
LTD (Long Term Depression)
Acesso em linha:http://journal.frontiersin.org/Journal/10.3389/fnmol.2012.00013/full
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