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Compensated endocytosis of LDL by hamster cells co-expressing the two distinct mutant LDL receptors defective in endocytosis and ligand binding

The low density lipoprotein receptor (LDLR) regulates the plasma cholesterol level by mediating endocytosis of LDL. We established stable hamster cell lines expressing two LDLRs with distinct functional defects, i.e., endocytosis and ligand binding. In the cell line expressing only I189D h/r (human-...

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Hoofdauteurs: Hiroyuki Yoshida, Masayuki Yokode, Akitsugu Yamamoto, Ryuichi Masaki, Toshinori Murayama, Hisanori Horiuchi, Toru Kita
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 1999-05-01
Reeks:Journal of Lipid Research
Onderwerpen:
LDL receptor
co-expression
endocytosis
familial hypercholesterolemia
Online toegang:http://www.sciencedirect.com/science/article/pii/S0022227520321167
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