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Synthesis of Substituted α-Trifluoromethyl Piperidinic Derivatives

A comprehensive survey of pathways leading to the generation of α-trifluoromethyl monocyclic piperidinic derivatives is provided (65 references). These compounds have been synthesized either from 6-membered rings e.g., pipecolic acid or lactam derivatives by introduction a trifluoromethyl group, fro...

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Principais autores: Sarah Rioton, Domingo Gomez Pardo, Janine Cossy
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2017-03-01
Serier:Molecules
Fag:
nitrogen heterocycles
fluorine
piperidine
trifluoromethyl group
ring expansion
cyclization
cycloaddition
Online adgang:http://www.mdpi.com/1420-3049/22/3/483
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