Adjunctive probiotic therapy sustains symptom relief in gastroesophageal reflux disease through gut microbiome-metabolome remodeling

ABSTRACT Proton pump inhibitors (PPIs) are standard therapy for gastroesophageal reflux disease (GERD), but long-term use causes dysbiosis, gastrointestinal side effects, and symptom relapse after discontinuation. Probiotics may offer adjunctive benefits by modulating the gut ecosystem. The study ai...

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Hlavní autoři:	Yingmeng Li, Qiong Li, Keyu Quan, Yong Xie, Ni Yang, Teng Ma, Longjin Zheng, Wei Zhou, Yalin Li, Hao Jin, Zhihong Sun, Yongfu Chen, Lai-Yu Kwok, Nonghua Lu, Weifeng Zhu, Wenjun Liu, Heping Zhang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology 2026-02-01
Edice:	mSystems
Témata:	gastroesophageal reflux disease proton pump inhibitor rabeprazole reflux disease questionnaire multi-omics microbiome-host interaction
On-line přístup:	https://journals.asm.org/doi/10.1128/msystems.01568-25
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