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Targeting macrophage Syk enhances responses to immune checkpoint blockade and radiotherapy in high-risk neuroblastoma

BackgroundNeuroblastoma (NB) is considered an immunologically cold tumor and is usually less responsive to immune checkpoint blockade (ICB). Tumor-associated macrophages (TAMs) are highly infiltrated in NB tumors and promote immune escape and resistance to ICB. Hence therapeutic strategies targeting...

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I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Deepak Rohila, In Hwan Park, Timothy V. Pham, Riley Jones, Elisabette Tapia, Kevin X. Liu, Pablo Tamayo, Alice Yu, Andrew B. Sharabi, Shweta Joshi
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Frontiers Media S.A. 2023-06-01
Rangatū:Frontiers in Immunology
Ngā marau:
Urunga tuihono:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1148317/full
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